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Dr. Stefanie Diana Hueber |
Current
Research |
Evolution and sequence pattern identification
of homeodomain proteins in a variety of multicellular organism.
A) Homeodomain
Protein Evolution
Homeodomain proteins are transcription factors that can be found in
nearly all sequenced organisms. The relationship, however, between
various groups of homeodomain proteins is unclear. Even for the best
described group of homeodomain proteins, the Hox proteins, the
relationship and functional orthologs of some Hox proteins have not
been resolved in the standard model organisms.
B) Identification
of Sequence
Patterns in Homeodomain
Proteins
Various homeodomain proteins have stricingly
different effects on development of an organism, even though their DNA
binding properties are basically indistiguishable. Their different
effect on gene transcription can be explained by protein protein
interaction, but so far not enough differences in their protein
sequences have been described to account for their differences in
developmental function.
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Academic
Qualifications
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| Biology Ph.D., Tuebingen University, Germany
(2004-2009) |
| Biology Diploma, Dresden University of Technology,
Germany (2001-2003) |
Professional
Experience |
| 2009-present Australian National University Canberra,
Postdoctoral Fellow |
| 2004-2009 PhD student, Max-Planck-Institute
for Developmental Biology, Tuebingen, Germany |
Prizes and Awards |
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Dresdner Bank
Scholarship, Dresden, Germany (2000-2001)
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1st
prize Biology-Olympics, Hessen, Germany (1997)
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Selected Publications |
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Stefanie D. Hueber Identification and functional analysis of Hox downstream genes in Drosophila,
University of Tuebingen, (2009)
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Petra Stoebe, Matthias A. S. Stein, Anette Habring-M?ller, Daniela Bezdan,
Aurelia Fuchs, Stefanie D. Hueber, Haijia Wu and Ingrid Lohmann, Multifactorial Regulation of a Hox Target Gene,
PLOS Genetics 5 (3), e1000412 (2009)
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Stefanie D. Hueber and Ingrid Lohmann, Shaping segments: Hox gene function in the genomic age,
BioEssays 30, 965-979 ( 2008)
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Stefanie D. Hueber, Daniela Bezdan, Stefan R. Henz, Martina Blank, Haijia Wu and Ingrid Lohmann,Comparative analysis of Hox downstream genes in Drosophila, Development 134,381-392 (2007)
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